DIFFERENCES IN CANCER ANTIGEN-125 AND HUMAN EPIDIDYMIS-4 LEVELS ON EPITHELIAL OVARIAN CANCER STADIUM I, II AND STADIUM III

TESIS

Abstract

By : dr. I.B.Rumbawa Pemaron

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Faculties : Fakultas Kedokteran

Department : PS. OBGYN

Ovarian cancer was one of the most common gynecologic cancer with incidence of 41.4 per 100,000 in the age group over 50 years, which was largely an epithelial type. Cancer Antigen 125 (CA-125) was mostly used tumor marker despite its low specificity and positive predictive value. The use of Human Epididymis-4 (HE4) either alone or in combination with CA-125 was proven to improve the accuracy of screening and monitoring of diseases. The purpose of this study was to determine the difference between the levels of CA-125 and HE-4 on epithelial ovarian cancer stage I, stage II and stage III. The method used was cross sectional, held at Sanglah Hospital, Denpasar since May 2014. The number of samples in this study were 30 people, consecutively taken, with 14 samples were included in stage I ovarian cancer, 4 samples were included in stage II ovarian cancer, and 12 samples were included in stage III ovarian cancer. The data was then processed using SPSS and found significant differences in the levels of CA-125 and HE-4 between ovarian cancer stage I and II (p=0,016 and p=0,001) and between ovarian cancer stage I and II (p=0,001 and p=0,001), but there were no significant differences in the levels of CA-125 and HE-4 between ovarian cancer stage II and III (p>0,05).

Keyword : Epithelial ovarian cancer, stadium I, stadium II and stadium III, CA-125, HE-4

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