DIFFERENCES OF CANCER ANTIGEN-125 AND HUMAN EPIDIDIMIS PROTEIN-4 LEVELS ON BENIGN, BORDERLINE TUMOR AND OVARIAN CANCER EPITHELIAL TYPE
By : dr. Sofie Nurani Praniti ABD
Faculties : Fakultas Kedokteran
Department : PS. OBGYN
Ovarian cancer is the seventh malignant disease among women worldwide with 239,000 new cases diagnosed in 2012. The majority of ovarian cancer patients come and diagnosed at an advanced stage when, and only less than 25% of ovarian cancer cases are diagnosed during stage I. Expression CA-125 and HE-4 and the difference between benign, borderline, and epithelial ovarian cancer is a major focus of researchers to detect possible malignant tumors at an early stage. Observational cross sectional analytic study on 33 patients suffering from ovarian tumor in Sanglah Hospital, Denpasar, performed from February 2015 to January 2016. A careful history taking, physical examination, gynecological examination and ultrasound had been previously done. CA-125 and HE-4 levels were tested by taking serum. Histopathologic examination carried out after the tumor successfully removed via laparotomy and categorized according to the criteria of epithelial ovarian tumors are benign, borderline and malignant. With independent t-test there were no differences in levels of CA-125 and HE-4 between benign and borderline ovarian tumors (p> 0.05), whereas between benign and borderline ovarian tumor with epithelial ovarian cancer there are different levels of CA-125 and HE-4 significantly (p <0.05). This study demonstrated the ability of tumor malignancy determinant using the value of tumor markers. Required further studies to be a material assessment to determine the reference value in predicting the incidence of malignancies.
Keyword : ovarian cancer, levels of CA-125, HE-4, malignancy, borderline