CORRELATION BETWEEN HISTOPATHOLOGIC GRADING AND CARCINOEMBRYONIC ANTIGEN LEVELS IN COLON CARCINOMA

TESIS

Abstract

By : I Wayan Wahyu Sutrisna

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Faculties : Fakultas Kedokteran

Department : PS. ILMU BEDAH

In assessing the prognosis of colon cancer patients, clinician use clinical indicators including; clinical stage, histopathological grade, and location of the tumor. Several previous studies propose one way to determine the prognosis of patients with colon cancer examination carcinoembryonic antigen levels (CEA) serum. This study aimed to confirm the relationship between levels of serum CEA and histopathological grading, tumor location, as well as the validity of the CEA in predicting poor prognosis in colon carcinoma patients. Our study design was a cross sectional study, samples were taken retrospectively implemented in digestive surgery department Sanglah Hospital. Data 88 patients were taken by consecutive sampling and test the CEA mean comparison with the Kruskal-Wallis test. Furthermore, the validity of a diagnostic test to find serum CEA levels in predicting the occurrence of poor prognosis in patients with colon cancer based on histopathological grading. In the analysis of the relationship histopathological grading and serum CEA levels p value of 0.0001, which showed a significant relationship (p < 0.05). Analysis of the relationship of tumor location and serum CEA p value of 0.4412, which showed no significant correlation (p value > 0.05). Sensitivity, specificity. Positive and negative predictive value of serum CEA in predicting the occurrence of a poor prognosis based on histopathological grading was 98.7%, 77.8%, 97.5%, and 87.5% (CI 95%). Serum CEA levels to be higher in tumors with histopathological grading well, and there is a significant relationship between histopathological grading and levels of CEA. The validity of CEA levels to predict the occurrence of poor prognosis in colon cancer based on histopathological grading has good sensitivity and specificity values that can be used for the purpose of patient education and therapy monitoring.

Keyword : carcinoembryonic antigen (CEA), colon cancer, histopathological grading.

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