RELATIONS OF BREASTFEEDING WITH IMMUNOGLOBULINE E TOTAL SERUM LEVEL IN ASTHMATIC CHILDREN

TESIS

Abstract

By : Putu Jerry Eka Rahayu Pande

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Faculties : Fakultas Kedokteran

Department : PS. ILMU KESEHATAN ANAK

Asthma is a chronic disease with the incidence increasing every years. Coverage of exclusive breastfeeding in Indonesia tends to decrease. Breast milk contains soluble CD14 so as to provide protection from the occurrence of asthma by preventing the formation of IgE. This study aims was to determine the relationship of the duration and exclusiveness of breastfeeding with total serum IgE levels. This study is a cross sectional study. A total of 43 subjects were recruited consecutively in Sanglah Hospital Denpasar and several practice of pediatrician in Denpasar. On study subject serum total IgE levels was examined and a history about previous breastfeeding also collected. Normality of the data was tested with descriptive methods calculate the ratio of skewness. The bivariate analysis with linear regression and multivariate analysis using ANCOVA. P <0.05 was significant. There was 43 subjects consisting of 21 men and 22 women. The mean age of the sample 7.84 years. The mean duration of breastfeeding 14.16 months and the mean duration of ekskluisif breastfeeding was 2.44 months with a mean serum total IgE levels 805.56 IU / ml. Duration and exclusivity of breastfeeding was not associated with total serum IgE levels (df =7, F =0.985, P =0.460 ; df =2, F =1.273, P =0.294). The absence of exposure to cigarette smoke significantly associated with total serum IgE levels (df =1, F =6.467, P =0.016). There were no statistically significant association between duration and exclusivity of breastfeeding with total serum IgE levels in children with asthma. The absence of cigarette smoke exposure associated with total serum IgE levels. Further research needs to be conducted with a prospective method to avoid recall bias.

Keyword : breastfeeding duration, breastfeeding exclusivity, immunoglobulin E total serum, children, asthma.

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