NEONATORUM ASPHYXIA AS RISK FACTORS FOR SENSORINEURAL HEARING LOSS

TESIS

Abstract

By : dr. Putu Verita Wulandari

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Faculties : Fakultas Kedokteran

Department : PS. ILMU KESEHATAN ANAK

Neonatorum asphyxia is a spontaneous and regular respiratory failure at birth or sometime after birth, characterized by hypoxemia, hypercarbia and acidosis. This condition can cause tissue damage permanently or temporarily. One of the most frequent sequelae symptoms of neonatal asphyxia is sensorineural hearing loss. Based on the above objectives of this study is to prove the asphyxia neonatorum as a risk factor of sensorineural hearing loss. Observational studies with prospective cohort designs with neonatal study subjects 62 neonates consisted of 31 neonates of asphyxia group and 31 neonates without asphyxia born and or treated at Sanglah Hospital Denpasar from March 2013 to March 2014 or until the number of samples were met. Subjects that fulfills inclusion criteria were tested for a thympanometric examination, first oto acustic emission (OAE) examination at <1 months and second OAE examination at 3 months. Statistical analysis with chi-square test and cox regression. Hearing loss was obtained from 83.9% in asphyxia based on first OAE (p <0.001, RR 6.5; 95% CI 2.6-16.4), to 80.6% in second OAE (p <0.001; 6.3; 95% CI 2.5-15.9). Risk factors of prematurity in the first OAE (p 0.301; RR 1.3; 95% CI 0.8-2.2) and second OAE (p 0.425; RR 1.2; 95% CI 0.7-2.1). Multivariate analysis of asphyxia neonatorum was a risk factor for sensorineural hearing loss (adjusted RR 5.6, 95% CI 1.9-17.1, p 0.002). Prematurity, aminoglycoside therapy and low birth weight are not risk factors for sensorineural hearing loss.

Keyword : otoacoustic emissions, hearing loss, neonatorum asphyxia

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