Antidiabetic Activity Palm (Arengapinnata)Exudats and Histology Pancreatic Male Wistar Rats induced by Alloxan



By : Gusti A. Prianka A. S.

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Faculties : Fakultas Matematika dan Ilmu Pengetahuan Alam

Department : S1 Farmasi

Palm (Arenga pinnata) exudats is a part of a palm that has potency as a antidiabetic agent Palm (Arenga pinnata) exudats is containing calcium which has role in glucose metabolic process induced by glucokinase enzyme. The limited data of potential anti-diabetic activity of fresh palm (Arenga pinnata) exudats intercepted for 12 hours encourage writer to held this study. Male wistar rats were used in this study. The diabetic condition was induced by 120 mg/kg BW alloxan via intraperitoneal The animals were divided into 6 groups: normal control, negative control (Aquadest), positive control (Glibenclamide 0.45 mg/kg BW), and three treatment groups (dose variation of palm (Arenga pinnata) exudats 1.5 mL, 3.5 mL, 4.5 mL) given for 28 days. Futhermore, the blood glucose levels were measured by a glucose test and histopatology study was held to observe the islet of Langerhans. The is then processed by satistic analysed. The result showed a difference in average blood glucose levels right after alloxan induction and after 28 days treatment. Palm (Arenga pinnata) exudats was capable of lowering blood glucose levels significantly (p<0.05) compared to the negative control group and had a larger average of lowering blood glucose levels compared to the positive control group. Histopathology study showed palm (Arenga pinnata) exudats in these wistar-strained rats induced by alloxan had not been able to repair the islet of Langerhans conditions.

Keyword : Palm (Arenga pinnata) exudats, calcium, antidiabetic, alloxan, glibenclamide

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