PREVALENCE Escherichia coli EXTENDED SPECTRUM BETALACTAMASE (ESBL) IN URINE SPECIMENS IN INSTALASI MIKROBIOLOGI KLINIK RSUP SANGLAH DURING JULY 2013 - DECEMBER 2013

SKRIPSI

Abstract

By : Yulia Aventa Anugerahani

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Faculties : Fakultas Kedokteran

Department : PS. PENDIDIKAN DOKTER

Nowdays, the persistence of high morbidity Urinary Tract Infection(UTI) due to Escherichia coli (E.coli) on population is also accompanied by an increase in antibiotic resistance. The study was conducted to determine the prevalence of E.coli producing Extended Spectrum Beta Lactamase (ESBL) in urine specimens which cultured in Instalasi Mikrobiologi Klinik RSUP Sanglah since July 2013 until in December 2013. This study used a descriptive epidemiological study to determine the prevalence of ESBL E.coli in urine specimens by taking the data of urine spesimenes were examined in Instalasi Mikrobiologi Klinik RSUP Sanglah during July to December 2013. Among 183 cases with E.coli, 53 cases identified as E.coli producing ESBL enzymes. Characteristics of patients with E.coli producing ESBL, 75,47% are male, mean age is 54,54 years and 92,45% were not admitted to the ICU. Antibiotic that resistant to ESBL E.coli such Ampicillin, Cefuroxime, Ceftazidime, Cefotaxime, Ciprofloxacin, Levofloxacin and Trimethoprim- Sulfamethoxazole. While antibiotics that sensitive to E.coli producing ESBL were Imipenem, Meropenem, Nitrofurantoin,and Gentamicin. It can be concluded that quarter ESBL E.coli is find in UTIs due to E.coli infection in RSUP Sanglah Denpasar, need observed as alarm against multi drug resistance. Treatment of UTI needs a careful approach adhering to recommended antibiotic guidelines in order to prevent emergence of multi drug resistant organisms.

Keyword : E.coli, Extended Spectrum Beta Lactamase, Sensitivity Pattern

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