NO INSIDENCE OF ACTIVE LUNG TUBERCULOSIS FOR 3 MONTHS MONITORING AFTER ISONIAZIDE PREVENTION THERAPY IN PATIENTS WITH HIV

TESIS

Abstract

By : I Gede Putu Jarwa Antara

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Faculties : Fakultas Kedokteran

Department : PS. ILMU PENYAKIT DALAM

Isoniazide prevention therapy or IPT is very efficacious to prevent tuberculosis incidence for individu living with HIV and have been recomended by WHO. Application for this recommendation have not been applied in all of nations as a guideline. Both IPT and ARV therapy can reduce tuberculosis risk. In Indonesia IPT itself have not been applied as guideline, it is only held in several hospital. This study was held to assess the incidence of tuberculosis after giving IPT. TB is a infection associated with HIV which can be cured dan preventable. There a prove that TB can make worsen progression of HIV as a immune activation. HIV infection also a greatest risk factor for development primary or reactivation tuberculosis. This study was cohort prospective desciptive study. Sample was taken by consecutive sampling at Wangaya HIV clinic. IPT was given for six months to all sample which fulfill the requirements and monitor for tuberculosis incidence every month through questionaire for tuberculosis screening. If there were tuberculosis signs and symptoms, a confirmation test with bacterial and imaging examination will be held. Tuberculosis incidence will be monitored for 6 months therapy and continued for 3 months after IPT. This study enrolled 122 sample which all of the sample given IPT. With 5 sample had incompleted IPT treatment, consist of 1 sample (0,82%) died during IPT and 4 samples (3,28%) were lost to follow up. Based on gender, sample were consist of 55,6% males and 44,6% females. Generally tuberculosis incidence at 6 months IPT was 0 per 100 person year and 3 months after IPT was 0 per 100 person year. The tuberculosis incidence was not found at 6 months IPT and 3 months after IPT and patient showed adherence for IPT.

Keyword : Tuberculosis incidence, IPT, HIV, TB

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