Correlation Between Blood Total Natural Killer Cell With Cervical Cancer Clinical Stadium

TESIS

Abstract

By : I Gusti Made Aswara

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Faculties : Fakultas Kedokteran

Department : PS. ILMU PENYAKIT DALAM

Cervical cancer is still a frightening disease for the community as a very high risk of death for the sufferer. Natural killer cells, or NK cells are cytotoxic lymphocytes that are important in the innate immunity system. NK cells are partly responsible for the development of cancer cells. NK cell levels in the blood, allegedly associated with a high risk of developing the cancer cells become more malignant forms. In patients with low NK cell count will increase the risk of cervical cancer. The purpose of this study was to determine the relationship between the number of blood NK cells with clinical stage of cervical cancer. This is a cross-sectional analitic study conducted from April to September 2016, involved 60 women who had come to the clinic and inpatient Sanglah General Hospital Denpasar. Based on the clinical stage of cervical cancer, 30 patients studied, obtained 8 (26.7%) classified as stage 1, stage 2 as many as 10 people (33.3%), stage 3 of 7 people (23.3%) and stage 4 by 5 people (16.7%). The independent T-test against NK cells and cervical cancer found the number of NK cells mean of 215.97 124.97 in the case group and 291.13 108.19 in the control group, obtained a mean difference of 75.17 and the value of CI 95% are between 14.76 to 135.57, with p = 0,016 which means there are differences between the mean number of NK cells significantly between groups of cervical cancer than the control group of healthy women.

Keyword : Cervical cancer, Natural Killer Cell

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