CATHEPSIN B SERUM LEVEL IN CERVICAL EPITHELIAL CANCER IS HIGHER THAN CERVICAL PRECANCER LESION

TESIS

Abstract

By : dr. A.A.Bagus Indra Permadi

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Faculties : Fakultas Kedokteran

Department : PS. OBGYN

Cervical cancer is the one of the most prevalent cancer in women and the highest cause of women’s death in developing countries. Cysteine protease as Cathepsin B is known to be involved in cancer invasion process, metastasis, tumout angiogenesis, and apoptosis. Measuring Cathepsin B level has the potensial to be early cell invasion marker, prognosis, and therapy outcome in cervical cancer. This was a cross sectional study involving 45 patients (consecutive sampling) diagnosed with cervical cancer and cervical precancer lesion in Sanglah General Hospital, started from March 2015. Data was processed using SPSS 17.0 for Windows. This study found 45 patients, comprised with 22 cervical cancer patients and 23 cervical precancer lesion patients. And there was significant difference of serum Cathepsin B level between cervical cancer group and cervical precancer lesion group 223,15 + 118,33 vs 57,25 + 26,16, P < 0,05). It was concluded that there was difference of serum Cathepsin B level between cervical cancer and cervical precancer lesion.

Keyword : Cathepsin B, Cervical Cancer, Cervical Precancer Lesion.

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