COMPARISON OF HISTOPATHOLGICAL FIGURES OF MALE WHITE RATS (Rattus norvegicus) STOMACH GIVEN MEFENAMIC ACID AND DEXAMETHASONE
By : Yoakim Wilson Sakura
Faculties : Fakultas Kedokteran Hewan
Department : Profesi Dokter Hewan
At surgery all the instruments involved are in sterile conditions in order not exposed infection agents that can slow down the speed of wound healing. To prevent that, the surgical practitioner will provide treatment in the form of antibiotics and anti-inflammatory, good anti-inflammatory steroids or non-steroidal diversified. This study aims to determine differences in histopathologic picture of the stomach of white rats (Rattus norvegicus) male given mefenamic acid and dexamethasone. White male rats were divided into 3 treatment groups, each treatment consisting of 10 rats, each rat made cuts on his body and sewn back, and were treated postoperatively for 3 days. I treated mice are mice that were only given amoxicillin. II treated mice are mice that were given amoxicillin combination mefenamic acid. Rat III is treated mice given amoxicillin combination of dexamethasone. On day -7 and day 14 performed euthanasia on 5 rats in each treatment group, and then the stomach of mice that had been euthanation collected for histopathologic examination, and observed the gastric mucosal epithelial cell necrosis, degeneration and infiltration of inflammatory cells and given scoring. Histopathologic examination results were analyzed using methods kruscalwallis, the results showed on day 7 and day 14 of treatment was not significantly different (p> 0.05) against cell necrosis and inflammatory cell infiltration, but significantly different (P <0 , 05) against cells undergoing degeneration. At the Mann Whitney test, indicating cells undergoing degeneration in mice treated II significantly different (P <0.05) in mice treated I and III. There are differences between the mice treated I, II and III where mice treated II has a higher level of damage than treatments I and III seen from the spread of cell degeneration.
Keyword : Amoxicillin, Mefenamic acid, Dexamethasone, gastric histopathology