EFFECT OF ETHYL ACETATE PARTITION PARE FRUIT EXTRACT (MOMORDICA CHARANTIA) TO DECREASE BLOOD GLUCOSE WHITE RAT (RATTUS NORVEGICUS) THE INDUCED STREPTOZOTOZIN

TESIS

Abstract

By : Muhammad Ghufron Ananta

Email : anantafreaks@yahoo.com

Faculties : Fakultas Kedokteran Hewan

Department : Profesi Dokter Hewan

This aim of study was to determine the efficacy of ethyl acetate extract partition bitter melon the reduction blood glucose levels of diabetes mellitus white rats (Rattus norvegicus) diabetes mellitus. Blood glucose levels was measured before injected streptozotocin and days 0, 4, 11, and 18 after the white rats is in experimental diabetes mellitus. Treatment (bitter melon extract and chloroform partition) was given after day 0 to day 18. This study consisted of four treatments and five repetitions that used completely randomized design. Five treatments are normal mice that became negative control (-) mice with diabetes mellitus positive control (+),diabetes mellitus rats 2%(200 mg/kg) bitter melon extration and diabetes mellitus rats with partition ethyl acetate 50 mg / kg. The results study showed significant rate from administration of etchyl acetat parttion from bitter melon extraction to reduction blood glucose in white rats.

Keyword : Diabetes Mellitus, Momordica charantia, Rattus norvegicus

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