Partisi N-heksana, Chloroform, Butanol, dan Ekstrak Buah Pare (Momordica charantia L.) Meningkatkan Berat Badan Tikus Putih Jantan (Rattus norvegicus) Diabetik Ekspremental

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Abstract

By : Ni Putu Evi Windari

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Faculties : Fakultas Kedokteran Hewan

Department : Profesi Dokter Hewan

Diabetes mellitus is a disease that can metabolism with multi etiology characterized by weight loss. Treatment can be given to provide traditional medicine. One type of plant that is widely used as a traditional medicine is the fruit of bitter melon (Momordica charantia L.). This research aimed to determine the efficacy of partition n-hexane, chloroform, butanol, and extract of bitter melon fruit (Momordica charantia L.) in increasing body weight of white male rats (Rattus norvegicus) ekspremental. This research using RAL with six treatments and five repetitions ie negative control, positive control, partitioning n-hexane, chloroform partition, partition butanol, and extract of bitter melon fruit (Momordica charantia L.). The data was analyz by ANOVA and Duncan's test. All treatment made diabetic condition by streptozotocin injection except negative control. The scientists was weight the white male rat the day before injection by streptozotocin. Weigh the on days -1 (before injecting STZ), 0 (when the diabetic condition), 4 (after being given treatment), 11 and 18. The result after addition of n-hexane partition, chloroform, butanol, and extract of bitter melon fruit (Momordica charantia L.) able to increase weight of male rats (Rattus norvegicus) (P <0.05).

Keyword : bitter melon fruit extract, chloroform, diabetic ekspremental, n-hexane, partition butanol

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