Antidiabetic Activity Palm (Arengapinnata) sugar and Histology Pancreatic Male Wistar Rats induced by Alloxan

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Abstract

By : Amirul Amin

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Faculties : Fakultas Matematika dan Ilmu Pengetahuan Alam

Department : S1 Farmasi

Palm sugar (Arenga pinnata) is the result of processing palm exudats. Palm (Arenga pinnata) exudats that has potency as a antidiabetic agent sugar palm (Arenga pinnata) is containing calcium which has role in glucose metabolic process induced by glucokinase enzyme. The limited data of potential anti-diabetic activity of sugar palm (Arenga pinnata) encourage writer to held this study. Male wistar rats were used in this study. The diabetic condition was induced by 120 mg/kg BW alloxan via intraperitoneal The animals were divided into 6 groups: normal control, negative control (Aquadest), positive control (Glibenclamide 0.45 mg/kg BW), and three treatment groups (dose variation of sugar palm (Arenga pinnata) 2.57 mg/kg BW, 5.14 mg/kg BW, 10.28 mg/kg BW) given for 28 days. Futhermore, the blood glucose levels were measured by a glucose test and histopatology study was held to observe the islet of Langerhans. The is then processed by satistic analysed. The result showed a difference in average blood glucose levels right after alloxan induction and after 28 days treatment. Sugar palm (Arenga pinnata) was capable of lowering blood glucose levels significantly (p<0.05) compared to the negative control group and had a larger average of lowering blood glucose levels compared to the positive control group. Histopathology study sugar palm (Arenga pinnata) exudats in these wistar-strained rats induced by alloxan had not been able to repair the islet of Langerhans conditions.

Keyword : sugar palm (Arenga pinnata), calcium, antidiabetic, alloxan, glibenclamide

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