Ondansentron Increasing Successfull Oral Rehidration Efforts in Acute Diarrhea mild-moderate dehydration with vomiting
By : I Ketut Oka Sentana
Faculties : Fakultas Kedokteran
Department : PS. ILMU KESEHATAN ANAK
Diarrhea is a problem in young children worldwide. Dehydration and electrolyte imbalance in patients with diarrhea is often caused by vomiting. Ondansentron are potent receptor antagonists of serotonin 5-HT3. Vomiting that occurs in diarrhea suspected by stimulation of viral or bacterial pathogen against enterochromafin cells to release serotonin so that the administration of a selective 5-HT3 receptor antagonists can prevent vomiting. This study was conducted to determine the benefits of ondansentron and standard therapy of diarrhea in efforts to improve the success of oral rehydration, the incidence of vomiting, and hospital readmission after oral rehydration efforts were declared successful. The study used the design of double-blind randomized clinical trial. In this study, there were two groups that were arranged in parallel. After oral rehydration efforts and monitoring the frequency of vomiting on the fast track for rehydration, the rehydrated study subjects were allowed to return home with study medication and were given the appropriate dose and monitoring for 2 days, and the non-rehydrated subjects were treated at Sanglah Hospital and monitoring was made directly for 2 days. A total of 140 research subjects were put in ondansentron and placebo groups, respectively 70 people. Bivariate analysis of ondansetron administration increased successful oral rehydration efforts [RR 2.296 (95% CI, 1.125 to 4.689; p=0.021)], decrease the incidence of vomiting in the second hour [RR 2.53 (95% CI 1.22 to 5.26; p=0.012)], and no patients had hospital readmission after oral rehydration efforts were declared successful. There were significant increasing successful oral rehydration efforts, decreasing the incidence of vomiting in the second hour, and no patients were readmitted to hospital after oral rehydration efforts were declared successful.
Keyword : ondansentron, oral rehydration efforts, vomiting