Risk Factors of Dengue Hemorrhagic Fever in Children

TESIS

Abstract

By : Anastasia Asty Lebao

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Faculties : Fakultas Kedokteran

Department : PS. ILMU KESEHATAN ANAK

Dengue infection is one of major health problem in tropical and subtropical countries, with increasing spread and dengue endemic areas. The increament of dengue morbidity and mortality could be related with viral and host factors. According to WHO 2011 severe clinical manifestation of dengue infection are dengue hemorrhagic fever (DHF). This study was done retrospectively in case-control design. One hundred and fifty six subjects were consecutively recruited from medical record in Sanglah Hospital. Subjects were divided in two groups, with 78 subjects as case (DHF) and 78 subjects as control group (dengue fever). Data was collected from each subjects with clinical risk factors such as abdominal pain, persistent vomitting rash, hepatomegaly, and spontaneous bleeding. Laboratory data include leukocyte count, platelet count, and hematocrit level. All data was taken at admission. Chi squre test was done to assess bivariate analyse. Logistic regression was done to assess multivariate analyse. The P value <0.05 was considered significant. The study resulted hepatomegaly (OR 26.3 95%CI 5.736-120.162) and hematocrit level ?40% (OR 5.0 95%CI 2.323-10.701) at admission were associated with DHF. In conclusion, hepatomegaly and hematocrit level ?40% at time of admission were significance risk factors of DHF.

Keyword : dengue hemorrhagic fever, children, risk faktors

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